Smart biostimulants: how nanotechnology is transforming agriculture


Los bioestimulantes inteligentes tienen la capacidad para combinar nanopartículas con microorganismos beneficiosos, extractos naturales u otros compuestos bioactivos

In recent years, agriculture has taken a leap toward more efficient, sustainable, and precise solutions. Among them, a concept that is gaining increasing prominence has emerged: smart biostimulants. But the question that often arises is what makes them “smart.” The answer lies in their ability to combine nanoparticles with beneficial microorganisms, natural extracts, or other bioactive compounds, creating formulations capable of improving plant growth, development, and resilience in a more controlled and efficient way.

Their mode of action is based on the controlled release of nutrients and bioactive molecules, protection against abiotic and biotic stress, and the optimization of resource absorption and use. These properties make it possible to increase agricultural efficiency, reduce the use of chemical fertilizers and pesticides, and support sustainable, precision agriculture.

Hands holding a test tube containing a plant.
Their mode of action is based on the controlled release of nutrients and bioactive molecules.

What are nanoparticles and why are they key in agriculture?

Nanoparticles (NPs) are tiny materials ranging in size from 1 to 100 nanometers, with unique physical and chemical properties. In agriculture, they can be made up of macro- and micronutrients (N, P, K, Mg, Ca, S, Mn, B, Cu, Si, Zn, Ni, Fe, Mo) or organic materials such as lignin, starch, chitosan, cellulose, urea, or lipids.

Beyond their nutritional role, certain nanoparticles exhibit antimicrobial activity, which opens the door to solutions that nourish and protect at the same time.

Advantages of nanotechnology-based formulations

Biostimulants that incorporate nanomaterials stand out for their ability to:

  1. Increase nutritional efficiency, thanks to the controlled release of nutrients and the reduction of losses and environmental toxicity.
  2. Stimulate key physiological processes in the plant, including antioxidant pathways that strengthen the response to stress
  3. Protect against pathogens and pests, thanks to nanopesticides or encapsulated microorganisms.
  4. Promote sustainable practices, reducing the use of traditional chemical inputs.

Nanotechnology: a technology of the future for precision agriculture

Nanotechnology in agriculture is emerging as one of the most transformative innovations in the sector and a key tool for precision agriculture. Its application enables the development of nano-biofertilizers (NBFs) capable of improving plant growth, increasing stress resilience, and overcoming many of the limitations of conventional fertilizers.

NBFs can be produced through biological synthesis using microorganisms, encapsulating metallic nanoparticles or other organic compounds such as polysaccharides or chitosan. Although this technology is still in its early stages, its agronomic potential is high.

A plant sprouting from the soil
Nanotechnology in agriculture is emerging as one of the most transformative innovations in the sector.

Nanoparticles as biocontrol agents

The intensive use of pesticides has led to significant environmental impacts, making the development of more sustainable alternatives essential. In this context, nanotechnology offers an alternative through nano-pesticides and nano-fungicides, made from silver, copper, silicon dioxide, or zinc oxide nanoparticles, among others. These systems increase treatment effectiveness by enabling more precise formulations, such as nano-emulsions or nano-capsules, allowing for much more targeted application of biocontrol agents (enzymes, antibiotics, beneficial microorganisms, etc.), or even controlling certain diseases in a highly specific way—for example, silver nanoparticles against bacterial infections, zinc oxide nanoparticles as fungicides, or iron oxide nanoparticles against phytopathogenic bacteria.

Nanoparticles as biopesticides

The development of nano-emulsions, nano-gels, nanospheres, and nano-capsules opens the door to more sustainable methods. These formulations enable more efficient release, better wettability, greater biodegradability, and a lower risk of phytotoxicity. Their great promise is clear: to reduce the environmental impact of conventional pesticides and support systemic acquired resistance in plants.

Smart biostimulants
So far, most studies have been conducted in laboratory settings.

Current limitations of nano-biofertilizers

Despite the progress, nano-biofertilizers still face major challenges:

  • Limited field research: most studies are conducted in laboratory settings.
  • Lack of clear regulations: evidence-based standards and protocols are needed.
  • Concerns about ecotoxicity: further analysis is needed regarding their degradation and potential accumulation.

Low adoption in the agricultural sector: costs, lack of standardization, and limited awareness hinder their expansion.

Future outlook and challenges to overcome

But what truly makes them “smart”? The key lies in their ability to integrate nanoparticles with beneficial microorganisms, natural extracts, and other bioactive compounds, resulting in advanced formulations that improve crop growth, development, and resilience in a more controlled and efficient way.